At a glance
| Analyte | Creatinine |
|---|---|
| Also called | CREA, Serum creatinine |
| Method | Enzymatic, sarcosine oxidase |
| Sample type | Serum, Plasma, Urine |
| Panel | Renal |
| Discipline | Clinical chemistry |
| Brand | Mindray |
What Creatinine measures
Creatinine is produced by muscle at a fairly constant rate and cleared almost entirely by the kidneys, and that steadiness is what makes it the more specific of the two renal markers. Because production depends on muscle mass, the same concentration means different things in a large young adult and a frail elderly patient, which is why laboratories report an estimated glomerular filtration rate calculated from the creatinine alongside the raw value. The relationship is not linear: filtration can fall substantially before the creatinine leaves its reference interval, so a result at the upper end of normal in an older patient may already represent meaningful impairment. Creatinine is also used to stage chronic kidney disease and to adjust the dosing of drugs cleared by the kidney.
How Philippine laboratories run it
The Philippines has a large dialysis population and a heavy burden of diabetic and hypertensive kidney disease, so creatinine is one of the highest-volume chemistry assays on most benches, and it generates repeat testing on the same patients rather than one-off requests. Laboratories serving dialysis centres or nephrology clinics should size this reagent well above what their panel count implies. Because eGFR is calculated from it, any drift in the creatinine measurement propagates directly into a reported stage of kidney disease, which is a good argument for keeping both control levels running.
Analyzers it runs on
* BA-88A: Semi-automated: assay parameters are entered manually at setup.
Calibrator, controls and companion tests
Delivered with its calibrator, both control levels and the rest of the renal panel, on the same schedule as Creatinine.
Storage and handling
Refrigerated and kept closed when off the analyzer.
Buying Creatinine in the Philippines
Creatinine is supplied for the BS-600M, BS-430, BS-360E, BS-240Pro, BS-230 and BA-88A. We deliver it with Multi-Sera Calibrator and Chemistry Control Level 1, because a run held up waiting on a separate order costs the same shift a stock-out does. Delivery is scheduled against your monthly Creatinine count, so the bench is not rationing tests in the last week of the month. How we plan clinical chemistry supply.
Questions about Creatinine
What does the SOX in the Mindray CREA (SOX) product name mean?
It identifies the method: sarcosine oxidase, an enzymatic determination of creatinine. It is worth knowing which method your laboratory runs, because the older Jaffe chemistry and enzymatic methods do not always agree closely, and eGFR equations are derived against standardised creatinine values. If you are comparing results with another laboratory, the method is part of the explanation for any difference.
Can a normal creatinine still mean reduced kidney function?
Yes, and this is the assay’s main limitation. The relationship between creatinine and filtration rate is not linear, so filtration can decline substantially before the creatinine rises above the reference interval, particularly in patients with low muscle mass. That is why laboratories report an estimated GFR calculated from the creatinine rather than leaving the raw value to be interpreted alone.
Order Creatinine
Tell us your monthly Creatinine volume and we will quote a supply schedule for BS-600M. We reply within one business day.
Request a quotation